Archives - MSRD 2017

MSRD 2017 Coordinators

TIna Binesh, Claudia Dziegielewski, Maggie Hess, Alex Tigert, Siraj Zahr

 

 

We are excited to announce that the keynote speaker for MSRD 2017 is Dr. Peter Dirks

Dr. Peter Dirks
 
 
 
 
 
 
 
 
 
 
 

 

Dr. Peter Dirks graduated from Queen's University Medical School in Kingston, Ontario in 1989. Then, he completed his PhD in Molecular and Cellular Pathology in 1997 at the University of Toronto, his neurosurgery training at the University of Toronto in 1998 (Fellow of the Royal College of Surgeons, Canada, 1998) and his Paediatric Neurosurgery Fellowship training at L'hôpital Necker Enfants Malades (Paris) in 1998.

Dirks was appointed to Neurosurgical Staff at The Hospital for Sick Children (SickKids) and the University of Toronto in 1998 and appointed to the SickKids Research Institute's Developmental & Stem Cell Biology Program in 1999. He established his research laboratory to study brain tumours in the Arthur and Sonia Labatt Brain Tumour Research Centre at SickKids in 1999.

Dr. David Malkin

Dirks' clinical interests lie with the entire spectrum of paediatric neurosurgical practice, with emphasis on the surgical treatment of childhood brain tumours and brain vascular malformations. The long term goal of Dr. Peter Dirks' research program is to determine if a normal neural stem cell or progenitor cell is transformed into a brain tumour. Two different approaches are being used in his lab to study this question.

One approach involves a study of primary human brain tumours obtained from neurosurgical operations to determine if stem cell populations exist in brain tumours. The group is interested in finding out if there is a small population of cancer cells in a brain tumour that uniquely have the ability to maintain the tumour or can all brain tumour cells drive tumour growth? Dr. Dirks' lab isolated and characterized a cancer stem cell from human brain tumours of different phenotypes that express neural stem cell markers with stem cell-like behaviour in vitro . These cells were isolated from both low grade and high grade primary brain tumours (astrocytoma, glioblastoma, ependymoma, medulloblastoma, anglioglioma) and represented only a small fraction of the total tumour cell population. This subpopulation of tumour cells could be considered as cancer stem cells, because they share properties with normal neural stem cells and are necessary for maintaining tumour growth in vitro. The identification of the brain tumour stem cell has important implications for understanding the mechanisms of brain tumorigenesis. Because this cell represents only a small number of the total number of cells in a brain tumour, it suggests that therapy that spares this cell may explain tumour recurrence. Studies of a brain tumour stem cell will lead to further insight into the normal brain cell that is the target for brain tumorigenesis.

The second approach involves a study of normal neural stem cells, to attempt to understand key determinants of proliferation and self renewal in these cells. Dr. Dirks' research is focused on the study of the Sonic hedgehog (Shh) signalling pathway, because it has been found to be perturbed in primary human brain tumours (medulloblastomas), and because it has been shown to be critically important for normal brain development. Preliminary studies in our laboratory suggest that different Shh pathway members play important and distinct roles in neural stem cell proliferation and self renewal. A better understanding of how this pathway functions in normal neural stem cells may help us to better understand brain tumour proliferation and self renewal.

 
 
 
 
 
 
 
 
 
 

Oral Abstract Presenters

Johnny-Wei Bai, MD 1T8 Candidate.
Abstract Title: Cardiovascular Disease Guideline Adherence and Statin Use in Longstanding Type 1 Diabetes: Results From The Canadian Study of Longevity in Diabetes Cohort 
 
Karan Josh Abraham, MD/PhD Candidate. 
Abstract Title: Suppression of RNA-DNA Hybrids - Towards a Novel and Coherent Mechanism Governing Repetitive DNA Stability, Aging, and Neurodegenration  

 

Omri A. Arbiv CREMS Summer Research Scholar and MD 1T6 Candidate. 
Abstract Title: Risk Factors for Hematopoietic Stem Cell Transplantation in Inherited Bone Marrow Failure Syndromes 
 

Poster Category Winners

Basic Science: Paymon Azizi
Clinical Science: Alexander Koven
Public Health: Elise Fryml
Quality Improvement: Kyle Eastwood
Medical Education: Sydney McQueen
Health Services: Xiao Xiong Yu
First Year Award: Haniya Khan

Conference Booklet

Please see this link
 

Photos

Click here to check out the photos from MSRD 2016
 

Acknowledgements

  • Participants - they are the foundation of this conference and key to the future innovation in healthcare.
  • Dr. Neil Sweezey, CREMS Program Director
  • Ms. Lisa Charette, CREMS Program Coordinator
  • Ms. Sandy McGugan, Administrative Manager of MD/PhD Program 
  • Desmond She and Team Lab Coat (website development)
  • Justin Lam and Shara Nauth (photographers)
 

Sponsors

We would like to thank the following organizations for their contribution to MSRD 2016:

Ontario Medical Association Peters-Boyd Academy   UofT Medical Society